Search results for "Cholesterol synthesi"

showing 3 items of 3 documents

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–…

2019

International audience; Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol and the cholesterol metabolite 5alpha-cholestanol are widely used as surrogate markers of cholesterol synthesis and absorption, respectively. Increasing numbers of laboratories utilize a broad spectrum of well-established and recently developed methods for the determination of cholesterol and non-cholesterol sterols (NCS). In order to evaluate the quality of these measurements and to identify possible sources of analytical errors our group initiated the first international survey for cholesterol and NCS. The cholesterol and NCS survey was structured as a two-part survey which took place…

0301 basic medicineEndocrinology Diabetes and MetabolismClinical BiochemistryBiochemistryCholesterol balancechemistry.chemical_compound0302 clinical medicineEndocrinologySurveys and QuestionnairesPhytosterolABSORPTIONMedicineCholesterol absorptionPRECURSORSNormal laboratoryPhytosterols[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismSERUM PLANT STEROLSSitosterol3. Good healthCholestanolCholesterolAtherosclerosi030220 oncology & carcinogenesisCholesterol synthesisMolecular Medicinelipids (amino acids peptides and proteins)HumanCholesterol synthesisChromatography GasCholesterol synthesiCampesterolatherosclerosis; cholesterol absorption; cholesterol balance; cholesterol synthesis; phytosterols; surrogate markerLathosterolDeuterium labelledArticle03 medical and health sciencesHumansMolecular BiologyChromatographybusiness.industryCholesterolCell BiologyAtherosclerosisSitosterolsSterol030104 developmental biologychemistryChromatography Ga3121 General medicine internal medicine and other clinical medicine1182 Biochemistry cell and molecular biologyGas chromatographySurrogate markerbusiness[SDV.AEN]Life Sciences [q-bio]/Food and NutritionChromatography Liquid
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Plasma non-cholesterol sterols: a useful diagnostic tool in pediatric hypercholesterolemia.

2010

Current guidelines strongly recommend the identification of genetic forms of hypercholesterolemia (HC) during childhood. The usefulness of non–cholesterol sterols (NCS) in the diagnosis of genetic HC has not been fully explored. Plasma NCS were measured by gas chromatography/mass spectrometry (GC/MS) in 113 children with hypercholesterolemia affected by: autosomal dominant hypercholesterolemia (ADH), familial combined hyperlipidemia (FCHL), polygenic hypercholesterolemia (PHC), and in 79 controls to evaluate: i) plasma NCS profile in different genetic HC and ii) the usefulness of NCS for the diagnosis of HC beyond current clinical criteria. ADH was characterized by raised lathosterol/total …

Cholesterol synthesisMalemedicine.medical_specialtyMultifactorial InheritanceSettore MED/09 - Medicina InternaAdolescentHyperlipidemia Familial CombinedLathosterolIncreased Cholesterol Synthesisbehavioral disciplines and activitiesGas Chromatography-Mass SpectrometryHyperlipoproteinemia Type IIchemistry.chemical_compoundPredictive Value of TestsInternal medicineBlood plasmaMedicineHumansGenetic Predisposition to DiseaseChildhypercholesterolemiabusiness.industryCholesterolDiscriminant AnalysisPhytosterolsSitosterolsSterolFamilial combined hyperlipidemiaSterolsEndocrinologypediatricCholesterolchemistryItalyCase-Control StudiesPediatrics Perinatology and Child Healthlipids (amino acids peptides and proteins)FemalebusinessBiomarkersLipoproteinPediatric research
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Effects of Gestational Diabetes Mellitus on Cholesterol Metabolism in Women with High-Risk Pregnancies: Possible Implications for Neonatal Outcome

2022

Metabolic disorders in pregnancy, particularly gestational diabetes mellitus (GDM), are associated with an increased risk for adverse pregnancy outcome and long-term cardiometabolic health of mother and child. This study analyzed changes of serum cholesterol synthesis and absorption markers during the course of high-risk pregnancies, with respect to the development of GDM. Possible associations of maternal lipid biomarkers with neonatal characteristics were also investigated. The study included 63 women with high risk for development of pregnancy complications. Size and proportions of small low-density (LDL) and high-density lipoprotein (HDL) particles were assessed across trimesters (T1&nd…

cholesterol synthesis and absorptionEndocrinology Diabetes and Metabolismhigh-risk pregnancy; gestational diabetes; cholesterol synthesis and absorption; LDL and HDL particles; neonatal outcomeLDL and HDL particles cholesterol synthesis and absorption gestational diabetes high-risk pregnancy neonatal outcomehigh-risk pregnancygestational diabetesLDL and HDL particlesMolecular BiologyBiochemistryneonatal outcome
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